Clinical
Physical exam with vital signs, height, weight, BMI
Thorough history for baseline medical conditions
Comprehensive system review
Bowel movements
Respiratory symptoms
Dermatological conditions/rashes
Myalgias and arthralgias
Neurological symptoms
Blood work
CBC with differential
Metabolic panel including electrolytes, liver function, creatinine, CK, total bilirubin and glucose
TSH, free T4
Investigations *high toxicity risk
Chest x-ray
CT
ECG
By organ site, each section will include the presentation, timing of onset, prevalence or incidence, work-up for concerning signs and symptoms, and grading table of adverse effects with treatment by grade and plan for resumption of immunotherapy.